In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Richard Austin, Paul Lebeau, and Michel Chrétien explain that the human Q152H ProPCSK9 mutation acquires an unexpected novel function: protection against ER stress and liver injury by enhancing chaperone expression.
In this episode, Olurotimi O. Mesubi explains that the discovery of oxidation of CaMKII and O-GlcNAcylation differentially increased atrial fibrillation risk in type 1 and type 2 diabetic mice, and identified a new pathway with the potential to reduce atrial fibrillation in diabetes.
In this episode, Melania Capasso explains how mTOR is hyperactivated in microglia with age and causes increased translation of inflammatory mediators, thus critically regulating microglia priming.
Persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the differential effects of GLP-1 and GIP on insulin secretion in diabetes.
In this episode, Justin Taylor and colleagues identify the genomic characteristics and clonal origins of a unique and aggressive clinical syndrome involving clonally related hematologic malignancies and germ cell tumors.