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Viewpoint

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Clinical trials for COVID-19 should include sex as a variable
Evelyne Bischof, … , Jeannette Wolfe, Sabra L. Klein
Evelyne Bischof, … , Jeannette Wolfe, Sabra L. Klein
Published May 11, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI139306.
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Clinical trials for COVID-19 should include sex as a variable

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Abstract

This Viewpoint calls on investigators that are developing and testing therapeutic and prophylactic approaches for COVID-19 to design studies that are inclusive of male-female differences.

Authors

Evelyne Bischof, Jeannette Wolfe, Sabra L. Klein

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Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists
Maximilian F. Konig, … , Shibin Zhou, Chetan Bettegowda
Maximilian F. Konig, … , Shibin Zhou, Chetan Bettegowda
Published April 30, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI139642.
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Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists

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Abstract

Medications that target catecholamine-associated inflammation may prevent cytokine storm syndrome associated with COVID-19 and other diseases.

Authors

Maximilian F. Konig, Michael A. Powell, Verena Staedtke, Ren-Yuan Bai, David L. Thomas, Nicole M. Fischer, Sakibul Huq, Adham M. Khalafallah, Allison Koenecke, Ruoxuan Xiong, Brett Mensh, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Joshua T. Vogelstein, Susan Athey, Shibin Zhou, Chetan Bettegowda

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Prototype pathogen approach for pandemic preparedness: world on fire
Barney S. Graham, Kizzmekia S. Corbett
Barney S. Graham, Kizzmekia S. Corbett
Published April 30, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI139601.
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Prototype pathogen approach for pandemic preparedness: world on fire

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Abstract

Improved pandemic preparedness could be achieved by proactively managing emerging virus threats using available technologies.

Authors

Barney S. Graham, Kizzmekia S. Corbett

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Controversies surrounding female athletes with differences in sexual development
Ahmed Khattab, … , Ian Marshall, Sally Radovick
Ahmed Khattab, … , Ian Marshall, Sally Radovick
Published April 27, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI138479.
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Controversies surrounding female athletes with differences in sexual development

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Abstract

Authors

Ahmed Khattab, Ian Marshall, Sally Radovick

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Panic prescribing has become omnipresent during the COVID-19 pandemic
Arthur L. Caplan, Ross Upshur
Arthur L. Caplan, Ross Upshur
Published April 24, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI139562.
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Panic prescribing has become omnipresent during the COVID-19 pandemic

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Abstract

Lessons from the Ebola outbreak shows that it is possible to develop rapid and effective clinical research responses without relying on anecdote.

Authors

Arthur L. Caplan, Ross Upshur

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Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses
Allen C. Steere
Allen C. Steere
Published April 13, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI138062.
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Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses

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Abstract

Authors

Allen C. Steere

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Kidney diseases in the time of COVID-19: major challenges to patient care
Hamid Rabb
Hamid Rabb
Published April 6, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI138871.
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Kidney diseases in the time of COVID-19: major challenges to patient care

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Abstract

The current COVID-19 pandemic has affected everyone, but presents profound consequences for patients with kidney disease, health care providers, and biomedical researchers. In this Viewpoint, I will discuss a number of kidney-specific aspects of COVID-19 infection, noting therapeutic and basic research opportunities.

Authors

Hamid Rabb

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The COVID-19 pandemic and research shutdown: staying safe and productive
M. Bishr Omary, … , Reynold A. Panettieri, Jr., Kathleen W. Scotto
M. Bishr Omary, … , Reynold A. Panettieri, Jr., Kathleen W. Scotto
Published April 3, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI138646.
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The COVID-19 pandemic and research shutdown: staying safe and productive

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Abstract

This viewpoint addresses the major impact of the COVID-19 pandemic on biomedical research, the challenges created by the COVID-19 pandemic for research-intensive institutions, and what investigators can do to maintain some level of research activity while keeping their coworkers and trainees safe and engaged.

Authors

M. Bishr Omary, Jeetendra R. Eswaraka, S. David Kimball, Prabhas V. Moghe, Reynold A. Panettieri, Jr., Kathleen W. Scotto

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COVID-19 threatens health systems in sub-Saharan Africa: the eye of the crocodile
Elijah Paintsil
Elijah Paintsil
Published March 30, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI138493.
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COVID-19 threatens health systems in sub-Saharan Africa: the eye of the crocodile

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Abstract

The threat of Coronavirus Disease 2019 (COVID-19) to health systems in sub-Saharan Africa (SSA) can be compared metaphorically to a lake in Africa infested with a bask of crocodiles and the saying: “the eye of the crocodile.” In the lake, only the eyes of the crocodile appear on the surface while the rest of the body is submerged in water. In this Viewpoint, the eyes and the body of the crocodile represent the public health preparedness and health systems, respectively, in SSA.

Authors

Elijah Paintsil

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Alternative therapies in academic medical centers compromise evidence-based patient care
Donald M. Marcus
Donald M. Marcus
Published March 16, 2020
Citation Information: J Clin Invest. 2020. https://doi.org/10.1172/JCI137561.
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Alternative therapies in academic medical centers compromise evidence-based patient care

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Abstract

Authors

Donald M. Marcus

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