Status check: next-generation sequencing for infectious-disease diagnostics

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Next-generation sequencing (NGS) applications for the diagnostics of infectious diseases has demonstrated great potential with three distinct approaches: whole-genome sequencing (WGS), targeted NGS (tNGS), and metagenomic NGS (mNGS, also known as clinical metagenomics). These approaches provide several advantages over traditional microbiologic methods, though challenges still exist.

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Kyle G. Rodino, Patricia J. Simner

Molecular and cellular mechanisms underlying the failure of mitochondrial metabolism drugs in cancer clinical trials

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Karthik Vasan, Navdeep S. Chandel

Keeping translational research grounded in human biology

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Saptarsi M. Haldar

Building reproducible bridges to cross the “valley of death”

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Timothy M. Errington

Human brown fat and metabolic disease: a heated debate

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Rana K. Gupta

Human brown adipose tissue is not enough to combat cardiometabolic diseases

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André C. Carpentier, Denis P. Blondin

Does activating brown fat contribute to important metabolic benefits in humans? Yes!

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Aaron M. Cypess

FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches

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Peter-James H. Zushin, Souhrid Mukherjee, Joseph C. Wu

How should we think about the unprecedented weight loss efficacy of incretin-mimetic drugs?

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Yang Gou, Michael W. Schwartz

Optical coherence tomography: when a picture is worth a million words

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Authors

Simone Tzaridis, Martin Friedlander