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Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions
Gal Markel, … , Simcha Yagel, Ofer Mandelboim
Gal Markel, … , Simcha Yagel, Ofer Mandelboim
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):943-953. https://doi.org/10.1172/JCI15643.
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Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions

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Abstract

Research Article

Authors

Gal Markel, Dana Wolf, Jacob Hanna, Roi Gazit, Debra Goldman-Wohl, Yuval Lavy, Simcha Yagel, Ofer Mandelboim

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Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome
Yoram G. Weiss, … , Nichelle Raj, Clifford S. Deutschman
Yoram G. Weiss, … , Nichelle Raj, Clifford S. Deutschman
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):801-806. https://doi.org/10.1172/JCI15888.
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Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome

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Abstract

Research Article

Authors

Yoram G. Weiss, Alina Maloyan, John Tazelaar, Nichelle Raj, Clifford S. Deutschman

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Androgen receptor–mediated inhibition of cutaneous wound healing
Gillian S. Ashcroft, Stuart J. Mills
Gillian S. Ashcroft, Stuart J. Mills
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):615-624. https://doi.org/10.1172/JCI15704.
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Androgen receptor–mediated inhibition of cutaneous wound healing

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Abstract

Research Article

Authors

Gillian S. Ashcroft, Stuart J. Mills

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Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
Burkhard Becher, … , Brigit G. Durell, Randolph J. Noelle
Burkhard Becher, … , Brigit G. Durell, Randolph J. Noelle
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):493-497. https://doi.org/10.1172/JCI15751.
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Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

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Abstract

Research Article

Authors

Burkhard Becher, Brigit G. Durell, Randolph J. Noelle

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T cell homeostatic proliferation elicits effective antitumor autoimmunity
Wolfgang Dummer, … , Ralph A. Reisfeld, Argyrios N. Theofilopoulos
Wolfgang Dummer, … , Ralph A. Reisfeld, Argyrios N. Theofilopoulos
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):185-192. https://doi.org/10.1172/JCI15175.
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T cell homeostatic proliferation elicits effective antitumor autoimmunity

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Abstract

Research Article

Authors

Wolfgang Dummer, Andreas G. Niethammer, Roberto Baccala, Brian R. Lawson, Norbert Wagner, Ralph A. Reisfeld, Argyrios N. Theofilopoulos

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Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels
William A. Chutkow, … , Charles F. Burant, Elizabeth M. McNally
William A. Chutkow, … , Charles F. Burant, Elizabeth M. McNally
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):203-208. https://doi.org/10.1172/JCI15672.
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Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels

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Abstract

Research Article

Authors

William A. Chutkow, Jielin Pu, Matthew T. Wheeler, Tomoyuki Wada, Jonathan C. Makielski, Charles F. Burant, Elizabeth M. McNally

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Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor
Gregorio D. Chazenbalk, … , Sandra M. McLachlan, Basil Rapoport
Gregorio D. Chazenbalk, … , Sandra M. McLachlan, Basil Rapoport
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):209-217. https://doi.org/10.1172/JCI15745.
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Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

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Abstract

Research Article

Authors

Gregorio D. Chazenbalk, Pavel Pichurin, Chun-Rong Chen, Francesco Latrofa, Alan P. Johnstone, Sandra M. McLachlan, Basil Rapoport

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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Hiroshi Yamamoto, … , Daniel J. Drucker, Joel K. Elmquist
Hiroshi Yamamoto, … , Daniel J. Drucker, Joel K. Elmquist
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):43-52. https://doi.org/10.1172/JCI15595.
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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

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Abstract

Research Article

Authors

Hiroshi Yamamoto, Charlotte E. Lee, Jacob N. Marcus, Todd D. Williams, J. Michael Overton, Marisol E. Lopez, Anthony N. Hollenberg, Laurie Baggio, Clifford B. Saper, Daniel J. Drucker, Joel K. Elmquist

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Immune complex–mediated antigen presentation induces tumor immunity
Khadija Rafiq, … , Amy Bergtold, Raphael Clynes
Khadija Rafiq, … , Amy Bergtold, Raphael Clynes
Published July 1, 2002
Citation Information: J Clin Invest. 2002;110(1):71-79. https://doi.org/10.1172/JCI15640.
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Immune complex–mediated antigen presentation induces tumor immunity

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Abstract

Research Article

Authors

Khadija Rafiq, Amy Bergtold, Raphael Clynes

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Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
Xinping Zhang, … , Randy N. Rosier, Regis J. O’Keefe
Xinping Zhang, … , Randy N. Rosier, Regis J. O’Keefe
Published June 1, 2002
Citation Information: J Clin Invest. 2002;109(11):1405-1415. https://doi.org/10.1172/JCI15681.
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Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

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Abstract

Preclinical and clinical studies suggest a possible role for cyclooxygenases in bone repair and create concerns about the use of nonsteroidal antiinflammatory drugs in patients with skeletal injury. We utilized wild-type, COX-1–/–, and COX-2–/– mice to demonstrate that COX-2 plays an essential role in both endochondral and intramembranous bone formation during skeletal repair. The healing of stabilized tibia fractures was significantly delayed in COX-2–/– mice compared with COX-1–/– and wild-type controls. The histology was characterized by a persistence of undifferentiated mesenchyme and a marked reduction in osteoblastogenesis that resulted in a high incidence of fibrous nonunion in the COX-2–/– mice. Similarly, intramembranous bone formation on the calvaria was reduced 60% in COX-2–/– mice following in vivo injection of FGF-1 compared with either COX-1–/– or wild-type mice. To elucidate the mechanism involved in reduced bone formation, osteoblastogenesis was studied in bone marrow stromal cell cultures obtained from COX-2–/– and wild-type mice. Bone nodule formation was reduced 50% in COX-2–/– mice. The defect in osteogenesis was completely rescued by addition of prostaglandin E2 (PGE2) to the cultures. In the presence of bone morphogenetic protein (BMP-2), bone nodule formation was enhanced to a similar level above that observed with PGE2 alone in both control and COX-2–/– cultures, indicating that BMPs complement COX-2 deficiency and are downstream of prostaglandins. Furthermore, we found that the defect in COX-2–/– cultures correlated with significantly reduced levels of cbfa1 and osterix, two genes necessary for bone formation. Addition of PGE2 rescued this defect, while BMP-2 enhanced cbfa1 and osterix in both COX-2–/– and wild-type cultures. Finally, the effects of these agents were additive, indicating that COX-2 is involved in maximal induction of osteogenesis. These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair.

Authors

Xinping Zhang, Edward M. Schwarz, Donald A. Young, J. Edward Puzas, Randy N. Rosier, Regis J. O’Keefe

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