Ebola virus causes severe hemorrhagic fever and is readily transmitted through contact with or inhalation of aerosolized biological fluids from infected individuals. Vaccines against this deadly virus are currently in development. As Ebola outbreaks...
Published July 13, 2015

Alcohol abuse is a major risk factor for morbidity and disability throughout the world, and treatment options are limited for this complex psychiatric condition. In this episode, Leandro Vendruscolo and colleagues demonstrate that administration of ...
Published June 29, 2015

The autoimmune disease systemic lupus erythematosus (SLE) is characterized by increased type I IFN and circulating apoptotic cell-derived autoantigens (AC-Ags), both of which drive autoantibody production by B cells. In this episode, John Mountz, Hu...
Published June 22, 2015

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and destroy fetal platelets.  Intracranial hemorrhage (ICH) is the most seriou...
Published April 23, 2015

The inherited disorder dyskeratosis congenita is characterized by short telomeres, mucocutaneous abnormalities, and bone marrow failure. The underlying genetic mutations are known in ~40% of cases and are found within genes associated with telomere ...
Published April 20, 2015

Mutations in the RAS oncogene are present in almost 25% of all cancers. Direct targeting of RAS for limiting these cancers has been challenging; therefore, elucidation of the pathways downstream of RAS has potential to provide therapeutic t...
Published March 23, 2015

The inherited form of blindness retinitis pigmentosa (RP) results from a progressive loss of photoreceptors. RP-associated mutations directly promote the death of rod cells, which are required for vision in low light, and indirectly promote the subs...
Published March 23, 2015

Retinitis pigmentosa (RP) is an inherited degenerative eye disease that results from the presence of mutations in rod-associated genes. Cone cells, which mediate day light vision, also progressively degrade in RP; however, the mechanisms that mediat...
Published March 23, 2015

Synaptic plasticity, or the ability of synapses to strengthen or weaken connections, is thought to underlie learning and memory. In this episode, Erwin Van Meir, Donald Rainnie, and Yoland Smith discuss their work, which identifies brain-specific an...
Published March 13, 2015

Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes and Luke Bolter reveal that the canonical WNT signaling pathway drives cholangiocarc...
Published February 17, 2015