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JCI This Month
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Epigenetic consequences of disturbed blood flow
The development of atherosclerotic plaques typically occurs in regions of arteries that have disturbed blood flow. While blood flow disturbances are known to alter endothelial gene expression and function, it is not clear how altered blood flow indu...
Published May 27, 2014
Examining RASA1 in vascular malformation
Capillary malformation-arteriovenous malformation (CM-AVM) results from inactivating mutations in the gene encoding RAS p21 protein activator (RASA1); however, RASA1 is expressed in multiple tissues, and it is not clear how RASA1 m...
Published May 16, 2014
Dendritic cell-dependent inhibition of malaria immunity
Induction of type I interferon (IFN) signaling is critical for host defense against most viruses; however, for some pathogens, including the parasite that causes malaria, induction of type I IFN-mediated pathways enhances host susceptibility to dise...
Published May 12, 2014
Neural peptidase regulates itch
Chronic itch is a common symptom and complaint for many dermatological patients. While some patients find relief with antihistamines, many do not, and the underlying pathways responsible for itch are poorly understood. In this episode, Martin Steinh...
Published May 8, 2014
Broadly neutralizing HIV-1 antibody identified in a lupus patient
Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved epitopes and display unique characteristics that suggest that their development may be limited by...
Published March 10, 2014
Pancreatic cancer properties describe gemcitabine response
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly forms of cancer, primarily due to the resistance of PDAC tumors to current therapeutic strategies. Several lines of evidence suggest that ineffective delivery of chemotherapy agents t...
Published March 10, 2014
Exploring presenilin-1-associated familial Alzheimer's disease
Familial Alzheimer's disease (FAD) is an early on-set, hereditary form of neurological disease with variable pathophysiology that is often associated with loss of cerebellar function and amyloid plaque formation. Diego Sepulveda-Falla and collea...
Published March 3, 2014
Prenatal environment influences the adult airway
Vitamin A and its active metabolite retinoic acid (RA) are essential for lung formation, though it is not clear if prenatal vitamin A deficiency influences postnatal lung development and function. In this episode, Wellington Cardoso provides evidenc...
Published February 3, 2014
A pharmacological approach to reversing aniridia
Nonsense mutations that lead to PAX6 haploinsufficiency cause congenital aniridia, a panocular condition that results in severe vision defects. Cheryl Gregory-Evans and colleagues hypothesized that suppression of nonsense mutations could in...
Published December 20, 2013
Maintaining T cell polyfunctionality
In order to protect the body from viruses and cancer, T cells must perform multiple functions, a feature that is often lost during chronic infection. Jonathan Schneck and colleagues examined the molecular mechanisms that maintain T cell polyfunction...
Published December 2, 2013
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American Society for Clinical Investigation
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