Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically
modified mice, or response of intact liver in vivo by injecting specific signaling substances.
This chapter discusses these signals with emphasis on their effects on LR. Autophagy
regulation is an important part of LR. Even though LR after partial hepatectomy is not
representative of types of liver injury most commonly seen in liver disease, it has been a very …

Liver regeneration after partial hepatectomy is a very complex and well‐orchestrated
phenomenon. It is carried out by the participation of all mature liver cell types. The process is
associated with signaling cascades involving growth factors, cytokines, matrix remodeling,
and several feedbacks of stimulation and inhibition of growth related signals. Liver manages
to restore any lost mass and adjust its size to that of the organism, while at the same time
providing full support for body homeostasis during the entire regenerative process. In …

Liver regeneration was recognized as a spectacular example of controlled tissue growth
ever since the gods of ancient Greece condemned Prometheus to be subjected to daily
partial hepatectomy by a bird, after he stole the secret of fire from the gods and passed it to
the humans. Despite many years of study of liver regeneration, the detailed nature of the
controlling factors which trigger or modulate this phenomenon has only recently started to
become understood. Much progress has been made in the elucidation of the mechanisms …