Reversal of diabetes in non-obese diabetic mice without spleen cell-derived ß cell regeneration
AS Chong, J Shen, J Tao, D Yin, A Kuznetsov, M Hara… - Science, 2006 - science.org
AS Chong, J Shen, J Tao, D Yin, A Kuznetsov, M Hara, LH Philipson
Science, 2006•science.orgAutoimmune destruction of β cells is the predominant cause of type 1 diabetes mellitus
(T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic
interventions prevent the development of T1DM in NOD mice, but few can induce its reversal
once established. Intervention with Freund's complete adjuvant, semi-allogeneic
splenocytes, and temporary islet transplantation has been reported to cure NOD mice of
established T1DM. Using the same approach, we report here that this treatment cured 32 …
(T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic
interventions prevent the development of T1DM in NOD mice, but few can induce its reversal
once established. Intervention with Freund's complete adjuvant, semi-allogeneic
splenocytes, and temporary islet transplantation has been reported to cure NOD mice of
established T1DM. Using the same approach, we report here that this treatment cured 32 …
Autoimmune destruction of β cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although β cells in these mice were not derived from donor splenocytes.
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