[HTML][HTML] Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure
M Gotthardt, RE Hammer, N Hubner, J Monti… - Journal of Biological …, 2003 - ASBMB
Titin is a giant protein responsible for muscle elasticity and provides a scaffold for several
sarcomeric proteins, including the novel titin-binding protein MURF-1, which binds near the
titin M-line region. Another unique feature of titin is the presence of a serine/threonine kinase-
like domain at the edge of the M-line region of the sarcomere, for which no physiological
catalytic function has yet been shown. To investigate the role (s) of the titin M-line segment,
we have conditionally deleted the exons MEx1 and MEx2 (encoding the kinase domain plus …
sarcomeric proteins, including the novel titin-binding protein MURF-1, which binds near the
titin M-line region. Another unique feature of titin is the presence of a serine/threonine kinase-
like domain at the edge of the M-line region of the sarcomere, for which no physiological
catalytic function has yet been shown. To investigate the role (s) of the titin M-line segment,
we have conditionally deleted the exons MEx1 and MEx2 (encoding the kinase domain plus …