[HTML][HTML] Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
JR Graff, BW Konicek, AM McNulty, Z Wang… - Journal of Biological …, 2000 - ASBMB
The PTENtumor suppressor gene is frequently inactivated in human prostate cancers,
particularly in more advanced cancers, suggesting that the AKT/protein kinase B (PKB)
kinase, which is negatively regulated by PTEN, may be involved in human prostate cancer
progression. We now show that AKT activation and activity are markedly increased in
androgen-independent, prostate-specific antigen-positive prostate cancer cells (LNAI cells)
established from xenograft tumors of the androgen-dependent LNCaP cell line. These LNAI …
particularly in more advanced cancers, suggesting that the AKT/protein kinase B (PKB)
kinase, which is negatively regulated by PTEN, may be involved in human prostate cancer
progression. We now show that AKT activation and activity are markedly increased in
androgen-independent, prostate-specific antigen-positive prostate cancer cells (LNAI cells)
established from xenograft tumors of the androgen-dependent LNCaP cell line. These LNAI …