[HTML][HTML] Upstream Stimulatory Factor Represses the Induction of Carnitine Palmitoyltransferase-Iऔ Expression by PGC-1
ML Moore, EA Park, JB McMillin - Journal of Biological Chemistry, 2003 - ASBMB
Transcriptional regulation of carnitine palmitoyltransferase-1औ (CPT-1औ) is coordinated
with contractile gene expression through cardiac-enriched transcription factors, GATA4 and
SRF. Metabolic modulation of CPT-1औ promoter activity has been described with the
stimulation of gene expression by oleate that is mediated through the peroxisome
proliferator-activated receptor (PPAR) pathway. The coactivator, peroxisomal proliferator-
activated receptor γ coactivator (PGC-1), enhances gene expression through interactions …
with contractile gene expression through cardiac-enriched transcription factors, GATA4 and
SRF. Metabolic modulation of CPT-1औ promoter activity has been described with the
stimulation of gene expression by oleate that is mediated through the peroxisome
proliferator-activated receptor (PPAR) pathway. The coactivator, peroxisomal proliferator-
activated receptor γ coactivator (PGC-1), enhances gene expression through interactions …