[HTML][HTML] Ca2+-dependent gene expression mediated by MEF2 transcription factors
F Blaeser, N Ho, R Prywes, TA Chatila - Journal of Biological Chemistry, 2000 - ASBMB
Ca 2+ induction of a subset of cellular and viral immediate-early activation genes in
lymphocytes has been previously mapped to response elements recognized by the MEF2
family of transcription factors. Here, we demonstrate that Ca 2+ activation of MEF2 response
elements in T lymphocytes is mediated in synergy by two Ca 2+/calmodulin-dependent
enzymes, the phosphatase calcineurin, and the kinase type IV/Gr (CaMKIV/Gr), which
promote transcription by the MEF2 family members MEF2A and MEF2D. Calcineurin up …
lymphocytes has been previously mapped to response elements recognized by the MEF2
family of transcription factors. Here, we demonstrate that Ca 2+ activation of MEF2 response
elements in T lymphocytes is mediated in synergy by two Ca 2+/calmodulin-dependent
enzymes, the phosphatase calcineurin, and the kinase type IV/Gr (CaMKIV/Gr), which
promote transcription by the MEF2 family members MEF2A and MEF2D. Calcineurin up …