Signal attenuation from ligand-activated epidermal growth factor receptor (EGFR) is
mediated in part by receptor endocytosis and trafficking to the lysosomal degradative
compartment. Uncoupling the activated EGFR from endocytosis and degradation has
emerged as a mechanism for oncogenic activation of the EGFR. The Abl nonreceptor
tyrosine kinase is activated by ligand-stimulated EGFR, but the role of Abl in EGFR signaling
has not been defined. Here we uncovered a novel role for the activated Abl kinase in the …