[HTML][HTML] Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling
E Zwick, H Daub, N Aoki, Y Yamaguchi-Aoki… - Journal of Biological …, 1997 - ASBMB
PC12 cells respond to a variety of external stimuli such as growth factors, neurotransmitters,
and membrane depolarization by activating the Ras/mitogen-activated protein kinase
pathway. Here we demonstrate that both depolarization-induced calcium influx and
treatment with bradykinin stimulate tyrosine phosphorylation of the epidermal growth factor
receptor (EGFR). Using a tetracycline-controlled expression system in conjunction with a
dominant-negative EGFR mutant, we demonstrate that depolarization and bradykinin …
and membrane depolarization by activating the Ras/mitogen-activated protein kinase
pathway. Here we demonstrate that both depolarization-induced calcium influx and
treatment with bradykinin stimulate tyrosine phosphorylation of the epidermal growth factor
receptor (EGFR). Using a tetracycline-controlled expression system in conjunction with a
dominant-negative EGFR mutant, we demonstrate that depolarization and bradykinin …