PURPOSE: Tumor cell genotype and phenotype have been considered the only
determinants supporting cancer growth and metastasis. This review focuses on the
published literature that suggests that tumor-microenvironment interaction has a decisive
role in controlling local cancer growth, invasion and distant metastasis. As this review
shows, genetic alterations in prostate cancer cells alone are not enough to confer metastatic
status without a supporting tumor microenvironment. Effective therapeutic targeting requires …