In the vast majority of cases, cancer continues to be an incurable disease when it has
spread beyond the primary organ. Most cancer research and therapy design to date has
focused on chemotherapy directed at killing the replicating tumor cells. Little attention has
been placed on targeting the microenvironments of the primary tumor site, the circulating
tumor cells, or the metastatic or secondary (target) tumor site and how cancer cells move
among them. To develop these targets, a better understanding of metastasis and the …