Molecular mechanisms in prostate cancer. A review.
R Mazzucchelli, F Barbisan, LM Tarquini… - Analytical and …, 2004 - europepmc.org
R Mazzucchelli, F Barbisan, LM Tarquini, AB Galosi, D Stramazzotti
Analytical and Quantitative Cytology and Histology, 2004•europepmc.orgGenetic studies have provided remarkable clues to the causes of prostate cancer (PCa). For
example, in addition to the expected role of androgens in facilitating the development of
PCa, the possibility that infections might lead to prostate cancer has been raised with the
identification of RNASEL and MSR1 as familial prostate cancer genes; that insight will
profoundly affect future studies and may ultimately lead to new approaches to the prevention
of prostate cancer. The identification of key molecular alterations in prostate cancer cells …
example, in addition to the expected role of androgens in facilitating the development of
PCa, the possibility that infections might lead to prostate cancer has been raised with the
identification of RNASEL and MSR1 as familial prostate cancer genes; that insight will
profoundly affect future studies and may ultimately lead to new approaches to the prevention
of prostate cancer. The identification of key molecular alterations in prostate cancer cells …
Genetic studies have provided remarkable clues to the causes of prostate cancer (PCa). For example, in addition to the expected role of androgens in facilitating the development of PCa, the possibility that infections might lead to prostate cancer has been raised with the identification of RNASEL and MSR1 as familial prostate cancer genes; that insight will profoundly affect future studies and may ultimately lead to new approaches to the prevention of prostate cancer. The identification of key molecular alterations in prostate cancer cells implicates carcinogen defenses, including GSTP1, growth factor signaling pathways (such as NKX3. 1, PTEN and p27) and androgens as critical determinants of the phenotype of PCa cells and defines specific targets for detection, diagnosis and treatment of PCa.
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