Molecular biology in prostate cancer
JR Cansino Alcaide, L Martínez-Piñeiro - Clinical and Translational …, 2006 - Springer
JR Cansino Alcaide, L Martínez-Piñeiro
Clinical and Translational Oncology, 2006•SpringerGenes involved in cancer generation are usually tumor suppressors and oncogenes.
Progressive genetic alterations in these genes are involved in the mechanisms of
tumorigenesis. In prostate cancer, additionally several chromosomal loci that should harbor
mutated genes have been proposed. Some genes have been found altered in prostate
cancer, such as PTEN, TP53, AR, RNASEL (HPC1), ELAC2 (HPC2), CDKN2A and MSR1
and those can be natural targets for new strategies of treatment. Besides, gene therapy has …
Progressive genetic alterations in these genes are involved in the mechanisms of
tumorigenesis. In prostate cancer, additionally several chromosomal loci that should harbor
mutated genes have been proposed. Some genes have been found altered in prostate
cancer, such as PTEN, TP53, AR, RNASEL (HPC1), ELAC2 (HPC2), CDKN2A and MSR1
and those can be natural targets for new strategies of treatment. Besides, gene therapy has …
Summary
Genes involved in cancer generation are usually tumor suppressors and oncogenes. Progressive genetic alterations in these genes are involved in the mechanisms of tumorigenesis. In prostate cancer, additionally several chromosomal loci that should harbor mutated genes have been proposed. Some genes have been found altered in prostate cancer, such as PTEN, TP53, AR, RNASEL (HPC1), ELAC2 (HPC2), CDKN2A and MSR1 and those can be natural targets for new strategies of treatment. Besides, gene therapy has been suggested to be suitable for prostate cancer treatment. This approach includesex vivo corrective therapy, suicide, and antisense therapy.
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