Akt-regulated pathways in prostate cancer
PK Majumder, WR Sellers - Oncogene, 2005 - nature.com
PK Majumder, WR Sellers
Oncogene, 2005•nature.comProstate cancer remains a major cause of cancer-related mortality. Genetic clues to the
molecular pathways driving the most aggressive forms of prostate cancer have been limited.
Genetic inactivation of PTEN through either gene deletion or point mutation is reasonably
common in metastatic prostate cancer and the resulting activation of phosphoinostide 3-
kinase, AKT and mTOR provides a major therapeutic opportunity in this disease as mTOR
inhibitors, HSP90 inhibitors and PI3K inhibitors begin to enter clinical development.
molecular pathways driving the most aggressive forms of prostate cancer have been limited.
Genetic inactivation of PTEN through either gene deletion or point mutation is reasonably
common in metastatic prostate cancer and the resulting activation of phosphoinostide 3-
kinase, AKT and mTOR provides a major therapeutic opportunity in this disease as mTOR
inhibitors, HSP90 inhibitors and PI3K inhibitors begin to enter clinical development.
Abstract
Prostate cancer remains a major cause of cancer-related mortality. Genetic clues to the molecular pathways driving the most aggressive forms of prostate cancer have been limited. Genetic inactivation of PTEN through either gene deletion or point mutation is reasonably common in metastatic prostate cancer and the resulting activation of phosphoinostide 3-kinase, AKT and mTOR provides a major therapeutic opportunity in this disease as mTOR inhibitors, HSP90 inhibitors and PI3K inhibitors begin to enter clinical development.
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