Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, β-catenin expression, and clinical features
Y Wei, JT Van Nhieu, S Prigent, P Srivatanakul… - Hepatology, 2002 - Elsevier
E-cadherin is a key cell adhesion protein implicated as a tumor/invasion suppressor in
human carcinomas and a binding partner of β-catenin, which plays a critical role in Wnt
signaling and in tumorigenesis. Here we report genetic and expression studies of E-
cadherin and β-catenin in hepatocellular carcinoma (HCC). Immunohistochemical analysis
of E-cadherin expression in 37 HCCs and adjacent nontumor tissues revealed important
variations among tumor samples, ranging from complete or heterogeneous down-regulation …
human carcinomas and a binding partner of β-catenin, which plays a critical role in Wnt
signaling and in tumorigenesis. Here we report genetic and expression studies of E-
cadherin and β-catenin in hepatocellular carcinoma (HCC). Immunohistochemical analysis
of E-cadherin expression in 37 HCCs and adjacent nontumor tissues revealed important
variations among tumor samples, ranging from complete or heterogeneous down-regulation …