The random amplified polymorphic DNA (RAPD) assay and related techniques applied to genotoxicity and carcinogenesis studies: a critical review
FA Atienzar, AN Jha - Mutation Research/Reviews in Mutation Research, 2006 - Elsevier
More than 9000 papers using the random amplified polymorphic DNA (RAPD) or related
techniques (eg the arbitrarily primed polymerase chain reaction (AP-PCR)) have been
published from 1990 to 2005. The RAPD method has been initially used to detect
polymorphism in genetic mapping, taxonomy and phylogenetic studies and later in
genotoxicity and carcinogenesis studies. Despite their extensive use, these techniques have
also attracted some criticisms, mainly for lack of reproducibility. In the light of their …
techniques (eg the arbitrarily primed polymerase chain reaction (AP-PCR)) have been
published from 1990 to 2005. The RAPD method has been initially used to detect
polymorphism in genetic mapping, taxonomy and phylogenetic studies and later in
genotoxicity and carcinogenesis studies. Despite their extensive use, these techniques have
also attracted some criticisms, mainly for lack of reproducibility. In the light of their …