[HTML][HTML] Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
J Yu, M Ni, J Xu, H Zhang, B Gao, J Gu, J Chen… - BMC cancer, 2002 - Springer
Background Hepatocellular carcinoma (HCC) presents one of the major health threats in
China today. A better understanding of the molecular genetics underlying malignant
transformation of hepatocytes is critical to success in the battle against this disease. The
methylation state of C5 of the cytosine in the CpG di-nucleotide that is enriched within or
near the promoter region of over 50% of the polymerase II genes has a drastic effect on
transcription of these genes. Changes in the methylation profile of the promoters represent …
China today. A better understanding of the molecular genetics underlying malignant
transformation of hepatocytes is critical to success in the battle against this disease. The
methylation state of C5 of the cytosine in the CpG di-nucleotide that is enriched within or
near the promoter region of over 50% of the polymerase II genes has a drastic effect on
transcription of these genes. Changes in the methylation profile of the promoters represent …
[HTML][HTML] Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of …
J Yu, H Zhang, J Gu, S Lin, J Li, W Lu, Y Wang, J Zhu - BMC cancer, 2004 - Springer
Background Astrocytoma is a common aggressive intracranial tumor and presents a
formidable challenge in the clinic. Association of altered DNA methylation patterns of the
promoter CpG islands with the expression profile of cancer-related genes, has been found in
many human tumors. Therefore, DNA methylation status as such may serve as an epigenetic
biomarker for both diagnosis and prognosis of human tumors, including astrocytoma.
Methods We used the methylation specific PCR in conjunction with sequencing verification …
formidable challenge in the clinic. Association of altered DNA methylation patterns of the
promoter CpG islands with the expression profile of cancer-related genes, has been found in
many human tumors. Therefore, DNA methylation status as such may serve as an epigenetic
biomarker for both diagnosis and prognosis of human tumors, including astrocytoma.
Methods We used the methylation specific PCR in conjunction with sequencing verification …