DNMT1 knockout delivers a strong blow to genome stability and cell viability
KD Brown, KD Robertson - Nature genetics, 2007 - nature.com
KD Brown, KD Robertson
Nature genetics, 2007•nature.comThe DNA methyltransferase DNMT1 is essential for cell viability in various mouse models,
but gene targeting in human tumor cells results in a viable line. This dilemma has now been
resolved using a new human DNMT1 knockout line, although new questions arise as to the
full extent of DNMT1 function in maintaining genome integrity.
but gene targeting in human tumor cells results in a viable line. This dilemma has now been
resolved using a new human DNMT1 knockout line, although new questions arise as to the
full extent of DNMT1 function in maintaining genome integrity.
The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.
nature.com