Although phosphate is important in skeletal mineral-ization, energy metabolism, and
multiple enzymatic processes, little has been understood about the regulation of phosphate
in health and disease until recently. Genetic and acquired disorders of phosphate
homeostasis have begun to reveal important mechanisms for the regulation of phosphate
metabolism. Candidate phosphate-regulating hormones (“phosphatonins”) have been
discovered, and their actions and interactions continue to be elucidated in an exciting area …