[HTML][HTML] Prostaglandin E2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line
XH Liu, A Kirschenbaum, M Lu, S Yao… - Journal of Biological …, 2002 - ASBMB
Hypoxia-induced up-regulation of vascular endothelial growth factor (VEGF) expression is a
critical event leading to tumor neovascularization. Hypoxia stimulates hypoxia-inducible
factor-1α (HIF-1α), a transcriptional activator of VEGF. Cyclooxygenase (COX)-2, an
inducible enzyme that catalyzes the formation of prostaglandins (PGs) from arachidonic
acid, is also induced by hypoxia. We reported previously that COX-2 inhibition prevents
hypoxic up-regulation of VEGF in human prostate cancer cells and that prostaglandin E 2 …
critical event leading to tumor neovascularization. Hypoxia stimulates hypoxia-inducible
factor-1α (HIF-1α), a transcriptional activator of VEGF. Cyclooxygenase (COX)-2, an
inducible enzyme that catalyzes the formation of prostaglandins (PGs) from arachidonic
acid, is also induced by hypoxia. We reported previously that COX-2 inhibition prevents
hypoxic up-regulation of VEGF in human prostate cancer cells and that prostaglandin E 2 …