Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by NN-dimethylsphingosine
DB Jendiroba, J Klostergaard, A Keyhani, L Pagliaro… - Leukemia research, 2002 - Elsevier
We evaluated the cytotoxicity of dimethylsphingosine (DMS) against four human leukemia
cell lines: two acute (HL60 and a multi-drug resistance MDR-positive derivative HL60-dox)
and two blast crisis chronic myelogenous leukemias (JFP1, from a treatment refractory
patient and K562), and against blasts isolated from 11 leukemia patients. Cell line viability
decreased proportionally to DMS concentration and treatment time (P< 0.001). HL60-dox
and JFP1 were the most sensitive, indicating DMS efficacy against human leukemia MDR …
cell lines: two acute (HL60 and a multi-drug resistance MDR-positive derivative HL60-dox)
and two blast crisis chronic myelogenous leukemias (JFP1, from a treatment refractory
patient and K562), and against blasts isolated from 11 leukemia patients. Cell line viability
decreased proportionally to DMS concentration and treatment time (P< 0.001). HL60-dox
and JFP1 were the most sensitive, indicating DMS efficacy against human leukemia MDR …