Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells
J Butler, D Lana, O Round, K LaMontagne - Prostaglandins & Other Lipid …, 2004 - Elsevier
Sphingosine 1-phosphate (S1P) is a pleiotropic lysophospholipid mediator involved in many
cellular responses, including transient calcium mobilization, activation of MAP kinase
signaling, inhibition of adenylyl cyclase and increased cell migration. S1P has been shown
to be an effective activator of vascular endothelial cells via the interaction with cell surface G
protein-coupled receptors (GPCRs), namely S1P-R (formerly EDG-R). The potent
immunomodulator, FTY720, is phosphorylated by sphingosine kinase (SK) to FTY720-P …
cellular responses, including transient calcium mobilization, activation of MAP kinase
signaling, inhibition of adenylyl cyclase and increased cell migration. S1P has been shown
to be an effective activator of vascular endothelial cells via the interaction with cell surface G
protein-coupled receptors (GPCRs), namely S1P-R (formerly EDG-R). The potent
immunomodulator, FTY720, is phosphorylated by sphingosine kinase (SK) to FTY720-P …