The genetics of human longevity

WS Browner, AJ Kahn, E Ziv, AP Reiner… - The American journal of …, 2004 - Elsevier
Many of the genes that affect aging and longevity in model organisms, such as mice, fruit
flies, and worms, have human homologs. This article reviews several genetic pathways that
may extend lifespan through effects on aging, rather than through effects on diseases such
as atherosclerosis or cancer. These include some of the genes involved in the regulation of
DNA repair and nuclear structure, which cause the progeroid syndromes when mutated, as
well as those that may affect telomere length, since shorter telomeres have been associated …