[HTML][HTML] Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart: cross-talk between cardiac hypertrophic signaling pathways
LJ De Windt, HW Lim, S Haq, T Force… - Journal of Biological …, 2000 - ASBMB
Multiple intracellular signaling pathways have been shown to regulate the hypertrophic
growth of cardiomyocytes. Both necessary and sufficient roles have been described for the
mitogen activated protein kinase 1 (MAPK) signaling pathway, specific protein kinase C
(PKC) isoforms, and calcineurin. Here we investigate the interdependence between
calcineurin, MAPK, and PKC isoforms in regulating cardiomyocyte hypertrophy using three
separate approaches. Hearts from hypertrophic calcineurin transgenic mice were …
growth of cardiomyocytes. Both necessary and sufficient roles have been described for the
mitogen activated protein kinase 1 (MAPK) signaling pathway, specific protein kinase C
(PKC) isoforms, and calcineurin. Here we investigate the interdependence between
calcineurin, MAPK, and PKC isoforms in regulating cardiomyocyte hypertrophy using three
separate approaches. Hearts from hypertrophic calcineurin transgenic mice were …