[HTML][HTML] Altered intracellular Ca2+ handling in heart failure
M Yano, Y Ikeda, M Matsuzaki - The Journal of clinical …, 2005 - Am Soc Clin Investig
M Yano, Y Ikeda, M Matsuzaki
The Journal of clinical investigation, 2005•Am Soc Clin InvestigStructural and functional alterations in the Ca 2+ regulatory proteins present in the
sarcoplasmic reticulum have recently been shown to be strongly involved in the
pathogenesis of heart failure. Chronic activation of the sympathetic nervous system or of the
renin-angiotensin system induces abnormalities in both the function and structure of these
proteins. We review here the considerable body of evidence that has accumulated to
support the notion that such abnormalities contribute to a defectiveness of contractile …
sarcoplasmic reticulum have recently been shown to be strongly involved in the
pathogenesis of heart failure. Chronic activation of the sympathetic nervous system or of the
renin-angiotensin system induces abnormalities in both the function and structure of these
proteins. We review here the considerable body of evidence that has accumulated to
support the notion that such abnormalities contribute to a defectiveness of contractile …
Structural and functional alterations in the Ca 2+ regulatory proteins present in the sarcoplasmic reticulum have recently been shown to be strongly involved in the pathogenesis of heart failure. Chronic activation of the sympathetic nervous system or of the renin-angiotensin system induces abnormalities in both the function and structure of these proteins. We review here the considerable body of evidence that has accumulated to support the notion that such abnormalities contribute to a defectiveness of contractile performance and hence to the progression of heart failure.
The Journal of Clinical Investigation