Sequential changes of nitric oxide levels in the temporal lobes of kainic acid-treated mice following application of nitric oxide synthase inhibitors and phenobarbital
N Kato, S Sato, H Yokoyama, T Kayama, T Yoshimura - Epilepsy research, 2005 - Elsevier
Although studies have indicated a close relationship between nitric oxide (NO) and kainic
acid (KA)-induced seizures, the role of NO in seizures is not fully understood. Here, we
quantified NO levels in the brain of KA-treated mice using EPR spectrometry to elucidate the
role of NO in KA-induced seizures. KA was administered to mice with or without pretreatment
with one of the following: NG-nitro-l-arginine methyl ester (l-NAME), an NO synthase (NOS)
inhibitor that acts on both endothelial NOS (eNOS) and neuronal NOS (nNOS); 7 …
acid (KA)-induced seizures, the role of NO in seizures is not fully understood. Here, we
quantified NO levels in the brain of KA-treated mice using EPR spectrometry to elucidate the
role of NO in KA-induced seizures. KA was administered to mice with or without pretreatment
with one of the following: NG-nitro-l-arginine methyl ester (l-NAME), an NO synthase (NOS)
inhibitor that acts on both endothelial NOS (eNOS) and neuronal NOS (nNOS); 7 …