Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy
JL Arbiser, SW Weiss, ZK Arbiser, F Bravo… - Journal of the American …, 2001 - Elsevier
Background: Tumors of endothelium range from benign hemangiomas of infancy to highly
malignant angiosarcomas of the elderly. Hemangiomas are the most common tumors in
infants and may affect up to 10% of all children. The biologic behavior of these lesions
ranges from self-resolving, in the case of hemangiomas and pyogenic granulomas, to lethal
metastatic neoplasms in the case of angiosarcoma. Although the clinical outcomes of these
diseases are easily distinguished, the biologic basis for these differences is not well …
malignant angiosarcomas of the elderly. Hemangiomas are the most common tumors in
infants and may affect up to 10% of all children. The biologic behavior of these lesions
ranges from self-resolving, in the case of hemangiomas and pyogenic granulomas, to lethal
metastatic neoplasms in the case of angiosarcoma. Although the clinical outcomes of these
diseases are easily distinguished, the biologic basis for these differences is not well …