Differential clonal expansion of CD4 and CD8 T cells in response to 4-1BB ligation: contribution of 4-1BB during inflammatory responses
C Takahashi, RS Mittler, AT Vella - Immunology letters, 2001 - Elsevier
Cell surface proteins of the tumor necrosis factor (TNF) family of receptors have been
intimately involved in inducing T cell death. A feature of these family members that is less
well studied is their ability to rescue T cells from apoptosis. One such member is 4-1BB; an
activation induced surface receptor on CD4 and CD8 T cells. This study demonstrates that
the costimulatory effects of 4-1BB, which was found to enhance clonal expansion, required
cross-linking of the receptor. The survival of the activated CD8 T cells following expansion …
intimately involved in inducing T cell death. A feature of these family members that is less
well studied is their ability to rescue T cells from apoptosis. One such member is 4-1BB; an
activation induced surface receptor on CD4 and CD8 T cells. This study demonstrates that
the costimulatory effects of 4-1BB, which was found to enhance clonal expansion, required
cross-linking of the receptor. The survival of the activated CD8 T cells following expansion …