[HTML][HTML] ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis
Y Al-Abed, D Dabideen, B Aljabari, A Valster… - Journal of Biological …, 2005 - ASBMB
MIF is a proinflammatory cytokine that has been implicated in the pathogenesis of sepsis,
arthritis, and other inflammatory diseases. Antibodies against MIF are effective in
experimental models of inflammation, and there is interest in strategies to inhibit its
deleterious cytokine activities. Here we identify a mechanism of inhibiting MIF pro-
inflammatory activities by targeting MIF tautomerase activity. We designed small molecules
to inhibit this tautomerase activity; a lead molecule," ISO-1 ((S, R)-3-(4-hydroxyphenyl)-4, 5 …
arthritis, and other inflammatory diseases. Antibodies against MIF are effective in
experimental models of inflammation, and there is interest in strategies to inhibit its
deleterious cytokine activities. Here we identify a mechanism of inhibiting MIF pro-
inflammatory activities by targeting MIF tautomerase activity. We designed small molecules
to inhibit this tautomerase activity; a lead molecule," ISO-1 ((S, R)-3-(4-hydroxyphenyl)-4, 5 …