[HTML][HTML] Macrophage migration inhibitory factor: a regulator of innate immunity

T Calandra, T Roger - Nature reviews immunology, 2003 - nature.com
T Calandra, T Roger
Nature reviews immunology, 2003nature.com
For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been
a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal
regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm
system and stress response that promotes the pro-inflammatory functions of immune cells. A
rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of
sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies …
Abstract
For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.
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