IL-13 is essential to the late-phase response in allergic rhinitis
S Miyahara, N Miyahara, S Matsubara, K Takeda… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: The pathophysiology of the early-and late-phase nasal response to
allergen challenge is not completely defined. Recent technical advances enable direct
monitoring of these responses in mice. OBJECTIVE: IL-13 is detected in the nasal
membranes of both human beings and mice with allergic rhinitis, but its role in disease
pathogenesis is unclear. We measured early and late nasal allergic responses after
treatment with soluble IL-13Rα2–IgG fusion protein (sIL-13Rα2–Fc), and in IL-13–deficient …
allergen challenge is not completely defined. Recent technical advances enable direct
monitoring of these responses in mice. OBJECTIVE: IL-13 is detected in the nasal
membranes of both human beings and mice with allergic rhinitis, but its role in disease
pathogenesis is unclear. We measured early and late nasal allergic responses after
treatment with soluble IL-13Rα2–IgG fusion protein (sIL-13Rα2–Fc), and in IL-13–deficient …