Recombinant canine IL-13 receptor α2-Fc fusion protein inhibits canine allergen-specific-IgE production in vitro by peripheral blood mononuclear cells from allergic …
L Tang, KL Boroughs, T Morales, K Stedman… - Veterinary Immunology …, 2001 - Elsevier
Human IL-13, like IL-4, is involved in the regulation of B-cell development, IgE synthesis and
allergic responses. However, because IL-13 does not affect either murine Ig class switching
or IgE production in vitro, the use of murine models to study the role of IL-13 in IgE-mediated
diseases has been limited. In this communication, we report that recombinant protein of
canine IL-13 (rcaIL-13) stimulates production of allergen-specific-IgE in vitro by peripheral
blood mononuclear cells (PBMC) from flea allergen-sensitized dogs, and that this …
allergic responses. However, because IL-13 does not affect either murine Ig class switching
or IgE production in vitro, the use of murine models to study the role of IL-13 in IgE-mediated
diseases has been limited. In this communication, we report that recombinant protein of
canine IL-13 (rcaIL-13) stimulates production of allergen-specific-IgE in vitro by peripheral
blood mononuclear cells (PBMC) from flea allergen-sensitized dogs, and that this …