Ischemia/reperfusion injury (IRI) is a multi-factorial antigen-independent inflammatory
condition that profoundly affects both early and long-term function of the allograft as
suggested by both clinical and experimental data. In recent years, the acute phase of IRI has
been increasingly viewed as part of the innate immune response. Identification of novel
molecular pathways and new insights into the mechanisms of known mediators of IRI have
established links among innate immunity, adaptive immune responses and organ …