The major causes of renal transplant loss are death from vascular, malignant or infectious
disease, and loss of the allograft from chronic renal dysfunction associated with the
development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is
the histologic description of the fibrosis, vascular and glomerular damage occurring in renal
allografts. Clinical programs rely on monitoring change in serum creatinine for identification
of patients at risk of CAN, but this change occurs late in the course of the disease, and …