[HTML][HTML] Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells
DL Hudson, M O'Hare, FM Watt, JRW Masters - Laboratory investigation, 2000 - Elsevier
Clonal analysis of human prostate epithelial cells was undertaken in order to identify stem
cells. Two types of colony were distinguished, termed type I and type II. Type I colonies were
relatively small and irregular and contained a loose mixture of differentiated and
undifferentiated cells. In contrast, type II colonies were large, round, and homogeneous,
consisting almost exclusively of small undifferentiated and dividing cells. The colony-forming
efficiency was 5.8%±1.8 for freshly isolated epithelial cells. There were approximately 10 …
cells. Two types of colony were distinguished, termed type I and type II. Type I colonies were
relatively small and irregular and contained a loose mixture of differentiated and
undifferentiated cells. In contrast, type II colonies were large, round, and homogeneous,
consisting almost exclusively of small undifferentiated and dividing cells. The colony-forming
efficiency was 5.8%±1.8 for freshly isolated epithelial cells. There were approximately 10 …