A murine model of factor XI deficiency
D Gailani, NM Lasky, GJ Broze Jr - Blood coagulation & …, 1997 - journals.lww.com
To facilitate investigations into the physiologic and pathologic roles of factor XI, we have
developed a murine model of severe factor XI deficiency using the technique of homologous
recombination in embryonic stem cells. The factor XI gene was disrupted by introducing a
neomycin phosphotransferase gene into the fifth exon. The activated partial thromboplastin
times of homozygous null mice were prolonged (158× 200 s) compared with wild type (25–
34 s) and heterozygous null (40–61 s) litter mates. Factor XI activity was absent from the …
developed a murine model of severe factor XI deficiency using the technique of homologous
recombination in embryonic stem cells. The factor XI gene was disrupted by introducing a
neomycin phosphotransferase gene into the fifth exon. The activated partial thromboplastin
times of homozygous null mice were prolonged (158× 200 s) compared with wild type (25–
34 s) and heterozygous null (40–61 s) litter mates. Factor XI activity was absent from the …