[HTML][HTML] Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
H Yagyu, T Kitamine, J Osuga, R Tozawa… - Journal of Biological …, 2000 - ASBMB
Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes esterification of cellular cholesterol.
To investigate the role of ACAT-1 in atherosclerosis, we have generated ACAT-1 null (ACAT-
1−/−) mice. ACAT activities were present in the liver and intestine but were completely
absent in adrenal, testes, ovaries, and peritoneal macrophages in our ACAT-1−/− mice. The
ACAT-1−/− mice had decreased openings of the eyes because of atrophy of the meibomian
glands, a modified form of sebaceous glands normally expressing high ACAT activities. This …
To investigate the role of ACAT-1 in atherosclerosis, we have generated ACAT-1 null (ACAT-
1−/−) mice. ACAT activities were present in the liver and intestine but were completely
absent in adrenal, testes, ovaries, and peritoneal macrophages in our ACAT-1−/− mice. The
ACAT-1−/− mice had decreased openings of the eyes because of atrophy of the meibomian
glands, a modified form of sebaceous glands normally expressing high ACAT activities. This …