Molecular and genetic mapping of the mouse mdx locus
JS Cavanna, G Coulton, JE Morgan, N Brockdorff… - Genomics, 1988 - Elsevier
JS Cavanna, G Coulton, JE Morgan, N Brockdorff, SM Forrest, KE Davies, SDM Brown
Genomics, 1988•ElsevierAbstract mdx is an X-linked muscular dystrophy mutant of the mouse and a putative homolog
of the human X-linked muscular dystrophy locus—Duchenne muscular dystrophy (DMD).
Utilizing a C57BL/10/Mus Spretus interspecific cross in which the mdx mutation was
segregating, we have constructed a detailed genetic map around the mdx locus on the
mouse X chromosome. We were unable to detect recombinants between mdx and exonic
probes derived from the human DMD gene. These genetic data support the contention from …
of the human X-linked muscular dystrophy locus—Duchenne muscular dystrophy (DMD).
Utilizing a C57BL/10/Mus Spretus interspecific cross in which the mdx mutation was
segregating, we have constructed a detailed genetic map around the mdx locus on the
mouse X chromosome. We were unable to detect recombinants between mdx and exonic
probes derived from the human DMD gene. These genetic data support the contention from …
Abstract
mdx is an X-linked muscular dystrophy mutant of the mouse and a putative homolog of the human X-linked muscular dystrophy locus—Duchenne muscular dystrophy (DMD). Utilizing a C57BL/10/Mus Spretus interspecific cross in which the mdx mutation was segregating, we have constructed a detailed genetic map around the mdx locus on the mouse X chromosome. We were unable to detect recombinants between mdx and exonic probes derived from the human DMD gene. These genetic data support the contention from biochemical studies (E. P. Hoffman, R. H. Brown, and L. M. Kunkel, 1987, Cell 51: 919–928) that DMD and mdx are homologous genes.
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