4-1BBL enhances anti-tumor responses in the presence or absence of CD28 but CD28 is required for protective immunity against parental tumors
BA Guinn, EM Bertram, MA DeBenedette… - Cellular …, 2001 - Elsevier
A20 is an aggressive BALB/c B cell lymphoma that, despite its expression of B7-2, rapidly
forms tumors in syngeneic mice. We have generated A20 transfectants expressing elevated
levels of B7-2 (A20/B7-2high) or 4-1BBL (A20/4-1BBLlow, mod, high) and found that mice
which were able to reject the A20/B7-2 or A20/4-1BBL transfectants were also resistant to
subsequent systemic challenge with the parental cell line. To assess whether the
effectiveness of 4-1BBL in enhancing anti-tumor immunogenicity was dependent on …
forms tumors in syngeneic mice. We have generated A20 transfectants expressing elevated
levels of B7-2 (A20/B7-2high) or 4-1BBL (A20/4-1BBLlow, mod, high) and found that mice
which were able to reject the A20/B7-2 or A20/4-1BBL transfectants were also resistant to
subsequent systemic challenge with the parental cell line. To assess whether the
effectiveness of 4-1BBL in enhancing anti-tumor immunogenicity was dependent on …