Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
Two diphosphonates containing the PCP bond, Cl2C (PO3HNa) 2 and H2C (PO3HNa) 2
retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced
by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized
rats in vivo.
retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced
by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized
rats in vivo.
Two diphosphonates containing the P-C-P bond, Cl2C(PO3HNa)2 and H2C(PO3HNa)2 retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.
AAAS