[HTML][HTML] Epithelial Na+ channels are activated by laminar shear stress
The degenerin/epithelial Na+ channel (ENaC) superfamily is a group of structurally related
ion channels that are involved in diverse biological processes, including responses to
mechanical stimuli. In renal cortical collecting ducts, changes in rates of perfusion affect Na+
reabsorption through an amiloride-sensitive pathway, suggesting that ENaC may be a
mechanosensitive channel. In this study, we examined whether ENaC expressed in oocytes
is regulated by laminar shear stress (LSS). A 1.8-mm (internal diameter) perfusion pipette …
ion channels that are involved in diverse biological processes, including responses to
mechanical stimuli. In renal cortical collecting ducts, changes in rates of perfusion affect Na+
reabsorption through an amiloride-sensitive pathway, suggesting that ENaC may be a
mechanosensitive channel. In this study, we examined whether ENaC expressed in oocytes
is regulated by laminar shear stress (LSS). A 1.8-mm (internal diameter) perfusion pipette …