[HTML][HTML] The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance
V Krasteva, GR Crabtree, JA Lessard - Experimental Hematology, 2017 - Elsevier
Highlights•BAF45a and BAF45d specify hemopoietic PBAF and BAF complexes, whereas
BAF45b and BAF45c are absent from hemopoietic tissue.•BAF45a expression is enriched in
long-term hemopoietic stem cells.•BAF45a is essential for hemopoietic stem cell
maintenance.•BAF45a function in hemopoietic cells is cell autonomous.The ability of
hemopoietic stem cells to self-renew and differentiate into downstream lineages is
dependent on specialized chromatin environments that establish and maintain stage …
BAF45b and BAF45c are absent from hemopoietic tissue.•BAF45a expression is enriched in
long-term hemopoietic stem cells.•BAF45a is essential for hemopoietic stem cell
maintenance.•BAF45a function in hemopoietic cells is cell autonomous.The ability of
hemopoietic stem cells to self-renew and differentiate into downstream lineages is
dependent on specialized chromatin environments that establish and maintain stage …