[HTML][HTML] Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARα-regulated gene expression in …
Y Jia, C Qi, P Kashireddi, S Surapureddi, YJ Zhu… - Journal of Biological …, 2004 - ASBMB
Nuclear receptor coactivator PBP (peroxisome proliferator-activated receptor (PPAR)-
binding protein) functions as a coactivator for PPARs and other nuclear receptors. PBP
serves as an anchor for TRAP (thyroid hormone receptor-associated proteins)/mediator
multisubunit cofactor transcription complex. Disruption of the PBP/TRAP220 gene results in
embryonic lethality around embryonic day 11.5 by affecting placental, cardiac, hepatic, and
bone marrow development. Because PPAR isoforms α, γ, and β/δ function as important …
binding protein) functions as a coactivator for PPARs and other nuclear receptors. PBP
serves as an anchor for TRAP (thyroid hormone receptor-associated proteins)/mediator
multisubunit cofactor transcription complex. Disruption of the PBP/TRAP220 gene results in
embryonic lethality around embryonic day 11.5 by affecting placental, cardiac, hepatic, and
bone marrow development. Because PPAR isoforms α, γ, and β/δ function as important …