[HTML][HTML] SOCS-1 protein prevents Janus kinase/STAT-dependent inhibition of β cell insulin gene transcription and secretion in response to interferon-γ
S Cottet, P Dupraz, F Hamburger, W Dolci… - Journal of Biological …, 2001 - ASBMB
In the pathogenesis of type I diabetes mellitus, activated leukocytes infiltrate pancreatic islets
and induce β cell dysfunction and destruction. Interferon (IFN)-γ, tumor necrosis factor-α and
interleukin (IL)-1β play important, although not completely defined, roles in these
mechanisms. Here, using the highly differentiated βTc-Tet insulin-secreting cell line, we
showed that IFN-γ dose-and time-dependently suppressed insulin synthesis and glucose-
stimulated secretion. As described previously IFN-γ, in combination with IL-1β, also induces …
and induce β cell dysfunction and destruction. Interferon (IFN)-γ, tumor necrosis factor-α and
interleukin (IL)-1β play important, although not completely defined, roles in these
mechanisms. Here, using the highly differentiated βTc-Tet insulin-secreting cell line, we
showed that IFN-γ dose-and time-dependently suppressed insulin synthesis and glucose-
stimulated secretion. As described previously IFN-γ, in combination with IL-1β, also induces …