Pax5: a master regulator of B cell development and leukemogenesis
J Medvedovic, A Ebert, H Tagoh, M Busslinger - Advances in immunology, 2011 - Elsevier
The B cell lineage of the hematopoietic system is responsible for the generation of high-
affinity antibodies, which provide humoral immunity for protection against foreign pathogens.
B cell commitment and development depend on many transcription factors including Pax5.
Here, we review the different functions of Pax5 in regulating various aspects of B
lymphopoiesis. At B cell commitment, Pax5 restricts the developmental potential of lymphoid
progenitors to the B cell pathway by repressing B-lineage-inappropriate genes, while it …
affinity antibodies, which provide humoral immunity for protection against foreign pathogens.
B cell commitment and development depend on many transcription factors including Pax5.
Here, we review the different functions of Pax5 in regulating various aspects of B
lymphopoiesis. At B cell commitment, Pax5 restricts the developmental potential of lymphoid
progenitors to the B cell pathway by repressing B-lineage-inappropriate genes, while it …